You have a septic patient with PCN allergies! and now you are in trouble to start appropriate antibiotics due to cross reactivity. This is an Italian based study, that studied the cross-reactivity and tolerability of aztreonam and imipenem-cilastatin, meropenem, and ertapenem among  patients with documented IgE-mediated hypersensitivity to penicillins.  They enrolled 212 patients with immediate … Continue reading Can we give carbapenems in patients with penicillins allergies?